Hormonal shifts during perimenopause and menopause can trigger increased melanin production, leading to dark spots and uneven skin tone that feel like they appear overnight. BRIGHLETTE™ is included in our formulations because it works across multiple stages of the pigmentation process, not just the surface. It's designed to help reduce the visibility of hyperpigmented areas and support a more even complexion over time.

As estrogen declines, skin cell turnover slows significantly, leaving a buildup of dull, dry surface cells that can make skin look flat and tired. PEELMOIST™ combines gentle enzymatic exfoliation with deep hydration, helping to clear that surface buildup while protecting the skin barrier underneath. For menopausal skin that's both drier and slower to renew, that dual function matters.

Reproage™ improves the complexion of both older and younger skin. Reproage peptide has been clinically proven to improve the roughness of skin by up to 41.3% in people aged between 50-55 years, while improving the overall complexion of the skin.

During menopause, the progenitor cells responsible for skin renewal slow down, contributing to increased roughness, dullness and visible texture changes. REPROAGE™ peptide is designed to support epidermal self-renewal at the cellular level, helping skin behave more like it did before hormonal changes took hold. Clinical testing showed particular effectiveness in the 50-55 age group, which aligns directly with the skin concerns our customers experience most.

SNAP-8™ is an advanced anti-ageing octapeptide and the latest evolution of the Argireline peptide family. SNAP-8™ peptide has been demonstrated to reduce muscle contractions, reducing wrinkle depth by up to 63% within 1 month.

Expression wrinkles deepen during perimenopause and menopause because falling estrogen reduces both collagen density and skin elasticity. Lines that were once temporary start to set permanently. SNAP-8™ peptide works with the skin's natural muscle movement to soften wrinkle depth over time, offering a topical alternative to injectables with a softer, more natural result.

SNAP-8™ works in harmony with your body

SNAP-8™ is biomimetic, which means it mimics the body’s natural function. Rather than cleaving the SNAP 25 protein, SNAP-8™ competes with it for a position in the SNARE complex. When SNAP-8™ replaces SNAP 25 the SNARE complex becomes destabilised and exocytosis cannot occur. Where anti-wrinkle injectables paralyse muscles, SNAP-8™ you could say relaxes them. You still get some muscle movement and facial expression because SNAP 8™ does not capture every SNAP 25 protein. The end result is a softer, more natural effect.

Wrinkle volume can be reduced by 21 percent in seven days and up to 63 percent in 28 days.

Several of our anti-ageing products are formulated with SNAP-8™ Peptide Solution, and recent studies show that by reducing muscle contractions with SNAP-8™, wrinkle depth is reduced by up to 21% in the first seven days, and up to 63% in one month of treatment. Fine lines and expression wrinkles fade, and the face looks smoother. It’s perfect for mature skin and also suitable for sensitive skin.

ACTIFCOL™ boosts collagen production and firmness within the skin.

Collagen loss accelerates sharply during menopause, with studies suggesting women can lose up to 30% of their skin collagen in the first five years after menopause. ACTIFCOL™ is included in our formulations specifically because it targets collagen synthesis and helps protect existing collagen from deterioration. For skin that's losing structural support due to hormonal change, that combination of building and protecting is essential.

ACTIFCOL™ advanced botanical ingredient has been clinically tested to provide an increase in key protein levels by up to 36.6%, providing a firmer and smoother complexion.

ACTIFCOL™ advanced botanical ingredient by Lipotec acts as a firming and tensing agent. It is a shiitake mushroom-based extract that can boost type I collagen synthesis and enhance PLOD1 levels, which further help to improve protein quality. It helps in reducing carbamylation process responsible for the deterioration of collagen. ACTIFCOL™ advanced botanical ingredient finds application for face, neck, decollete areas and mature skin.

Bodyfensine™ is a tripeptide which reinforces the skin’s natural defense mechanism by stimulating small peptides in your skin with antimicrobial properties. In clinical trials using BODYFENSINE™ peptide, the presence of sebum significantly decreased by 25% and skin moisturisation significantly increased by 38%.

Hormonal fluctuations during perimenopause can disrupt the skin's natural defence mechanisms, making it more vulnerable to breakouts, irritation and bacterial imbalance. BODYFENSINE™ peptide is designed to reinforce the skin's innate antimicrobial defences while helping to regulate sebum and improve hydration. It's particularly relevant for women experiencing hormonal acne alongside increased skin sensitivity.

BODYFENSINE™ peptide by Lipotec acts as an antimicrobial, anti-acne and protective agent. Is a tripeptide that reinforces the skin’s natural defense mechanism and lowers the risk of possible infections by external agent. Provides protection from widespread bacterial invasion and promote wound healing. In-vivo studies had shown a significant reduction in sebum (by 25%) and increase in moisturization by 38%. 

Matmarine™ works on sebum control, which in turn helps prevent skin breakouts. This active ingredient helps to prevent sebocytes from becoming mature (only mature sebocytes produce sebum) hence the skin becomes less oily, pore size is reduced, with the number of visible pores being reduced in order to provide less chance of producing blemishes.

Many women are surprised to experience oiliness, enlarged pores and breakouts during perimenopause, often for the first time since their teens. These changes are driven by shifting hormone ratios that can increase sebum production even as the rest of the skin becomes drier. MATMARINE™ targets sebum control at the cellular level, helping to reduce excess oiliness and minimise pore visibility without stripping moisture.

MATMARINE™ blue ingredient, obtained through biotechnology from a marine Pseudoalteromonas strain, is ideal for oily and combination skin. It is the perfect biotechnological ingredient to reduce extra shininess, pores, spots, and sebum.

Nocturshape™ provides a slimming effect and smoothes the skin by decreasing fat nodules during nocturnal (nighttime) intervals. NOCTURSHAPE™ blue ingredient smoothes the skin, providing a general firming improvement of the skin’s appearance.

Skin repair and renewal happen primarily overnight, but the efficiency of these processes declines with age and hormonal change. NOCTURSHAPE™ is designed to work with the body's natural circadian rhythm, targeting fat nodule reduction and skin firming during nighttime hours when the skin is most receptive. It's included in our body care formulations to help address the firmness and texture changes that many women notice during and after menopause.

NOCTURSHAPE™ blue ingredient has been clinically demonstrated to improve the skins firmness by up to 23%, with the appearance of skin firmness within 15 days of application.

NOCTURSHAPE™ blue ingredient by Lipotec is a preservative-free anti-cellulite and slimming active. It targets the expression of the circadian protein-nocturnin in adipocytes which peaks at early night, reduces thigh contour and smooths the skin relief due to a decrease of fat nodules at night. It also helps to reinforce the dermal matrix, enhancing the firmness of the skin. NOCTURSHAPE™ blue ingredient is used in body care formulations with specific night time application.

Eyeseryl® is a tetrapeptide with a demonstrated efficacy against puffy eyebags. In clinical tests, EYESERYL® peptide was able to demonstrate a noticeable reduction in eyebags within 14 days, with elasticity improving by 30% after 30 days.

The under-eye area is often the first place hormonal skin changes become visible. Thinner skin, reduced circulation and increased fluid retention during perimenopause and menopause can all contribute to persistent puffiness and under-eye bags. EYESERYL® is a targeted peptide with demonstrated efficacy against puffy eyebags, showing noticeable improvement within as little as 14 days in clinical testing.

Eyeseryl® is a tetrapeptide with anti-edema properties with proven efficacy in reducing puffy under eyebags in as little as 15 days.  It can be incorporated in cosmetic formulations such as gels, serums, and emulsions where a reduction of puffiness under the eyes is desired.

Studies were performed with Eyeseryl® at a very low concentration (1%) in order to define a minimum concentration for which an effect could be measured. Both eyebag volume and dark circles were moderately, but significantly reduced.  Up to 10% of the solution can be incorporated into formulations to obtain significant eyebag-reducing activity.

Eyedeline™ lessens eyebags and dark circles, smoothes eye contour lines and provides a glow for younger looking skin. EYEDELINE™ marine ingredient provides complete care for the eye area, achieving a younger and brighter look.

Dark circles, fine lines and a persistent tired appearance around the eyes are among the most common concerns women raise during menopause, even when sleep and lifestyle habits haven't changed. These changes are driven by collagen loss, reduced elastin and slower microcirculation in the delicate eye contour area. EYEDELINE™ is designed to address all three, working to improve skin tone, luminosity and firmness around the eyes.

EYEDELINE™ marine ingredient by Lipotec acts as an anti-puff and rejuvenating agent. Increases the degradation of bilirubin, promotes collagen I and elastin production, and inhibits the formation of AGEs, improving the skin tone and luminosity. It enhances the appearance of the eye contour area, smoothes the eye contour lines and combats the three signs of tiredness and aging typical of this delicate skin area like dark circles, eyebags and wrinkles.

Telangyn™ is a technically advanced peptide which decreases the appearance of facial redness. TELANGYN™ peptide fights the undesired effects caused by inflammation such as skin redness and dilated blood vessels, tissue degradation as well as post-inflammatory hyperpigmentation and dull skin.

Facial redness, flushing and visible blood vessels can intensify during perimenopause and menopause as the skin barrier weakens and inflammatory sensitivity increases. For many women, redness that was once occasional becomes more persistent and harder to manage. TELANGYN™ peptide is specifically designed to reduce the appearance of facial redness caused by excessive inflammatory response, targeting the underlying mechanism rather than just masking the surface.

Telangyn™ Peptide Solution is a cosmetic active developed by the Aimtec group of Lipotec designed to reduce the appearance of facial redness caused by inflammation.

Millions of people the world over suffer from skin redness linked to inflammatory overreactions which may cause general discomfort and influence our personal wellness in our daily and social life. Flushing skin, temporary or persistent erythema, telangiectasia, pustules, papules and itching may be experienced. Although these maladies usually apply to the facial area, they can also occur in the neck, ears, scalp and upper portions of the chest. What is clear is that there is an increase of skin inflammatory metabolites and reactions in people affected by facial redness and spider veins, suggesting that inflammation and its metabolites play a central role in these manifestations and disorders.

Telangyn™ is an innovative tetrapeptide specifically designed to decrease the appearance of facial redness and telangiectasia induced by an excessive inflammatory response. In skin facial disorders with redness and dilated capillaries, like rosacea, LL-37 expression is found to be abnormally high as well as IL-6 and IL-8 levels. In that it has been found that the skin’s response to inflammation and experimental sunburn lesions results in the release and increase of several pro-inflammatory cytokines and chemokines, including IL-6 and IL-8, it can be said that LL-37 and skin disorders with erythema are linked. TelangynTM works to reduce the release of interleukins (IL-6 & IL-8) induced by 37-amino-acid peptide (LL-37).

Cosmetic Benefits

• Fights skin redness caused by inflammation
• Fights post-inflammatory hyperpigmentation
• Reduces appearance of dialated blood vessels™

Delisens™ is specifically designed to restore the skin’s damaged barrier function and provide a protective effect, preventing further inflammation.

Skin sensitivity often increases significantly during menopause as falling estrogen weakens the skin barrier and heightens neurogenic inflammation. Skin that was never particularly reactive can suddenly become prone to stinging, itching, dryness and discomfort. DELISENS™ peptide is designed to calm that heightened sensitivity by restoring barrier function and reducing inflammatory signalling, while also improving hydration in very dry, reactive skin.

DELISENS™ peptide has been clinically demonstrated to increase hydration levels by up to 34%, ameliorating skin dryness, scaling, smoothness, softness and suppleness in sensitive skin.

DELISENS™ peptide by Lipotec acts as a soothing, anti-inflammatory, moisturising and repairing agent. It is a hexapeptide that attenuates neurogenic inflammation and relieves itch in sensitive skin. Restores the damaged barrier function and provides a photo-protective effect. Also decreases nagging pain sensation, discomfort and helps in re-epithelization of damaged skin. Delisens offers scaling, smoothness and softness to very dry sensitive. In vivo studies had shown its ability to improve the stinging feeling.

Vanistryl® is designed to increase the skin’s elasticity and to help visibly reduce the signs of scars and stretch marks. This active ingredient also helps to reconstruct extra cellular matrix components (collagen and elastin), providing a wound healing effect, while reducing skin tension (so it relaxes the skin). Importantly, this active ingredient works on both new and old scars and stretch marks.

Scar healing and stretch mark recovery can be slower and less effective in hormonally changing skin, where reduced collagen synthesis and weaker extracellular matrix make it harder for the skin to repair itself properly. VANISTRYL® works through multiple mechanisms, helping to protect connective tissue from degradation, support the reconstruction of collagen and elastin, and reduce skin tension around scarred areas. It's designed to improve the appearance of both old and new scars and stretch marks.

Vanistryl® by Lipotec is a combination of several active ingredients incorporated in Lipotec’s new delivery system that acts by different mechanisms to treat the appearance of scars and stretch marks that are already formed and avoiding the appearance of new ones.

Vanistryl® is a translucent gel containing:

• 1.87% Pseudoalteromonas Ferment Extract
• 0.025% Acetyl Tripeptide-30 Citruline
• 0.01% Pentapeptide-18

Vanistryl® protects connective tissue from degradation, helps to reconstruct the skin’s extra cellular matrix (ECM) components, provides a wound healing effect and reduces skin tension.  The overall effect is translated into a visible attenuation of old and recent scars and stretch marks in vivo.

Chromabright® is a powerful active ingredient which inhibits the production of melanin, aiding the brightening of the skin, while preventing photoaging.

Hyperpigmentation and uneven skin tone are among the most visible and persistent effects of hormonal skin change during menopause. Increased melanin production combined with slower cell turnover means dark spots can appear more readily and take longer to fade. CHROMABRIGHT® is a targeted brightening active that inhibits melanin production while also helping to protect against UV-induced skin damage, addressing both the cause and the consequence.

CHROMABRIGHT® molecule is a cutting-edge active ingredient which has been found to produce significant results between 30 and 60 days.

CHROMABRIGHT® molecule by Lipotec acts as a lightening agent. It brightens the skin safely, prevents photo-aging and also helps to prevent the skin damage caused by UV radiation. It possesses a photo-protective effect on human epidermal keratinocytes and shows neither cytotoxic effects nor any irritation or sensitization reaction.

Serilisene® is a peptide which restructures the skin, providing the appearance of firmer and more elastic skin density within 2 months.

The junction between the dermis and epidermis weakens during menopause as key structural proteins decline. This loss of cohesion contributes to the sagging, loss of density and reduced elasticity that many women experience. SERILESINE® peptide is designed to promote the synthesis of laminin-5, a protein essential for maintaining the connection between skin layers, helping to restore firmness and compactness from within.

Serilesine® is a hexapeptide; a synthesized sequence from the alpha chain of Laminin. This peptide retains many of the characteristics of the native protein, and promotes cell adhesion and proliferation. Certain features of the DEJ (the dermal epidermal junction) are altered by the aging process, such as the anchoring ability of keratinocytes, probably due to deficiencies in the expression of integrins as we age.

Laminin-5 synthesis has also been proved to decrease in aged skin. This causes a loss of contact between dermis and epidermis, and results in the skin losing elasticity and becoming saggy. The cohesion between dermis and epidermis is essential to maintain skin balance because it enables the transport of oxygen, nutrients and waste, contributing to the health of the epidermis. Serilesine’s synthetic hexapeptide from Laminin-1 is able to restore the skin’s normal function by promoting synthesis of Laminin-5, stimulating keratinocyte and fibroblast proliferation, inducing a redensifying effect on the dermis, and an improvement in skin elasticity, compactness, tonicity and smoothness.

COSMETIC BENEFITS

• Improves cell adhesion by enhancing synthesis of laminin-5
• Adhesion of cells to the basement membrane and among themselves provides firmness to the skin
• Increased contact between skin cells ensures correct nourishment and health
• Induces a significant increase in dermis density, improving skin compactness

Papain is a protein-degrading enzyme that is found naturally in papaya and is often referred to as a “plant-based pepsin”. Genova Skincare uses papain in exfoliating products to remove dead surface skin.

Slower cell turnover during menopause means dead surface cells accumulate more readily, leaving skin looking dull and rough. Papain is a gentle, plant-based enzyme derived from papaya that helps remove that surface buildup without the harshness of physical exfoliants or stronger chemical peels. It's a practical choice for menopausal skin that needs renewal support without added irritation.

Lactic Acid is a powerful ingredient that helps to reduce the visible signs of acne breakouts and the appearance of wrinkles.

As skin ages and hormonal changes take effect, the natural exfoliation process slows, and fine lines become more pronounced. Lactic acid is a naturally occurring alpha-hydroxy acid that supports surface renewal by gently dissolving the bonds between dead skin cells. It's one of the gentler AHAs, making it suitable for mature and sensitive skin types that need exfoliation without excessive irritation.

Lactic acid is a naturally occurring alpha-hydroxy acid (or AHA) produced by the fermentation of sugars. It is the alpha-hydroxy acid most frequently used in peel products.

Salicylic Acid works by removing the top layer of dead skin cells to reveal renewed skin underneath. In the case of acne sufferers, this means sweeping away blocked pores on the skin’s surface.

Hormonal fluctuations during perimenopause can trigger breakouts in women who haven't experienced acne in decades. Unlike water-soluble exfoliants that work only on the surface, salicylic acid is oil-soluble, meaning it can penetrate into pores to help clear blockages at a deeper level. It's included in our blemish-focused formulations for women dealing with hormonal breakouts alongside other menopausal skin concerns.

When it comes to skin-care products, there are two classes of acids you’ll see often: beta hydroxy acids (BHAs) and alpha hydroxy acids (AHAs). Salicylic acid is a beta hydroxy acid. Both alpha and beta hydroxy acids exfoliate the skin, but AHAs are water-soluble, while BHAs are oil-soluble. Examples of AHAs, for reference, include glycolic and lactic acids.

Generally, oil-soluble ingredients penetrate through the lipid (fat) layers between the skin cells more readily. In other words, oil-soluble ingredients can penetrate the skin at a deeper level than their water-soluble counterparts. AHAs work well on the skin’s surface to loosen old, dead skin and reveal fresh newer skin. Salicylic acid works deeper [and is] able to penetrate into the pores to unclog them.

Allantoin is a non-irritating ingredient which soothes and protects the skin. Allantoin effectively softens the skin and helps to protect it.

Menopausal skin is often more reactive and easily irritated than it was previously, making gentle, protective ingredients more important than ever. Allantoin is a non-irritating compound that soothes, softens and helps protect the skin barrier. It works well alongside more active ingredients, providing a calming base that helps reduce the risk of irritation from stronger actives in the same formulation.

In general, Allantoin is non-toxic and safe for cosmetic use. It’s non-irritating and is a gentle anti-ager in skincare and is good for most skin types, including sensitive skin or those with a range of skin conditions, because it has the additional functionality of being a calming agent.